Liver conditions

Common drugs that cause low alkaline phosphatase include cinacalcet, oral contraceptives, and other hormone replacement therapies.

The alkaline phosphatase normal ranges in adults range from 44 to 121 U/L (reference). These limits vary slightly from laboratory to laboratory.

Low alkaline phosphatase levels in patients with lupus can occur due to various causes. Commonly, medications, malnutrition, zinc & magnesium deficiency, hypothyroidism, severe anemia associated with lupus, and others.

You can lower alkaline phosphatase by working with your doctor to identify and treat the cause such as liver or biliary disease.

The main causes of marked elevations in alkaline phosphatase include biliary obstruction, liver diseases such as primary biliary cholangitis, transient hyperphosphatasemia in infancy and early childhood, liver transplant rejection, and others.

dangerous levels of alkaline phosphatase are marked elevations exceeding 4 or 5 times the upper limit of normal. However, the danger level depends on the cause of elevation.

A slightly elevated alkaline phosphatase level is caused by either physiological conditions (such as pregnancy, growing bones, or aging). It is also caused by disease conditions such as liver, biliary, bone, thyroid diseases, some cancers, etc.

Common symptoms of low alkaline phosphatase include poor bone health, easy fractures, bone pain, symptoms of zinc or magnesium deficiency, etc

Common causes of elevated alkaline phosphatase with normal liver enzymes include bone diseases, younger ages, pregnancy, some cancers, partial biliary obstruction, and others.